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Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel
We designed nanofibers that incorporate the tetrodotoxin binding peptide sequences from the voltage-gated sodium channel. These nanofibers allowed the specific binding and release of tetrodotoxin to achieve prolonged nerve blockade.
First steps in a long journey: Understanding the potential clinical consequences of immune responses to the Cas9 protein
Recent demonstration of immune responses to Cas proteins identify a critical risk in the eventual clinical application of Cas-mediated gene editing. In the accompanying paper we extend these findings by identifying promiscuous T-cell epitopes on Cas9 derived from Staphylococcus aureus.
Accelerating Synthetic Biotic Development with Gut-on-a-chip Technology
M. Tyler Nelson & Mark R. Charbonneau--This article provides additional details on a successful collaboration between the 711th Human Performance Wing, Air Force Research Laboratory and Synlogic Inc., to develop human gut-on-a-chip models for screening high potential synbiotics.
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Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel
We designed nanofibers that incorporate the tetrodotoxin binding peptide sequences from the voltage-gated sodium channel. These nanofibers allowed the specific binding and release of tetrodotoxin to achieve prolonged nerve blockade.
Nature Biotech 25th Anniversary
Celebrating 25 years of Nature Biotechnology with posts from authors of landmark papers published in the journal.
Looking back on co-abundance binning and what it meant for microbiomics and its authors
In this post, Dr. Henrik Bjørn Nielsen and Dr. Mathieu Almeida are traveling back in time to talk about their paper on co-abundance binning published in 2014 in Nature Biotechnology and how it affected their field and careers.
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Exploring what happened after the paper was published, from follow up studies to career impact.
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The covers from the monthly issues of Nature Biomedical Engineering.
