Functional studies of RNA pseudouridine (Ψ) modification have been limited by lacking quantitatively map individual Ψ sites transcriptome-wide. To address this challenge, Dai et al. developed BID-seq, a method for quantitative mapping of Ψ at single-nucleotide resolution.

We all produce and discharge excretions into the sewer. Correspondingly, sewerage can tell a lot about its contributory population. In the case of the ongoing COVID-19 pandemic, wastewater-based epidemiology can serve as a tool for population wide pathogen surveillance without compliance issues.