Here we design a two-input single protein logic gate for biological computation by allosterically wiring two inputs to a functional site of a protein.

We developed a new type of MOFs-based core-shell nanoagents that enables near infrared (NIR) light-triggered two distinct antitumor mechanisms, namely oxidative stress and calcium overload, with both of them contributing to the mitochondria-dysfunction-associated eradication of tumor cells.

Recent demonstration of immune responses to Cas proteins identify a critical risk in the eventual clinical application of Cas-mediated gene editing. In the accompanying paper we extend these findings by identifying promiscuous T-cell epitopes on Cas9 derived from Staphylococcus aureus.

M. Tyler Nelson & Mark R. Charbonneau--This article provides additional details on a successful collaboration between the 711th Human Performance Wing, Air Force Research Laboratory and Synlogic Inc., to develop human gut-on-a-chip models for screening high potential synbiotics.