A structurally well-defined platform is described here to organize thrombin-binding aptamers, enabling the synergistic effects of thrombin recognition and anticoagulation.

AKA: A method to make T-cells better tumor killers

In recent years there has been a growing interest for the development of molecular evolution techniques. We describe the birth of T7-DIVA system, an in vivo mutagenesis system for the fast directed evolution of proteins in a continuous manner and with minimal manipulation.

Story behind this article (Nat. Commun. 10.1038/s41467-020-20027-0): how did this project come about and some of the research results.

Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution - Massimo Kube, Fabian Kohler, Elija Feigl, Baki Nagel-Yueksel, Elena Marie Willner, Jonas Jörg Funke, Thomas Gerling, Pierre Marcel Stömmer, Maximilian Nicolas Honemann, Thomas Martin, Sjors Scheres, HD