Using Bio-functional Polymers – A Novel Therapeutic Approach to Prevent Proliferative Vitreoretinopathy
A bio-functional synthetic polymer that is able to perform the novel application of preventing intraocular retinal scarring without any adjuvant pharmacologic agents.
We developed a highly scalable algorithm, FLAMINGO, to reconstruct the 3D chromosome structures at unprecedented resolution and unraveled the structural basis of chromatin interactions, long-range QTLs and high-order multi-way interactions.
We identified a novel type II-A nuclease, FrCas9. It possesses comparable cutting efficiency to SpCas9 but with lower off-target effect. Furthermore, the specific 5'-NNTA-3' PAM enables FrCas9 to directly target the TATA-box to regulate gene expression.
We establish a novel approach to expand the utilization of FDR estimation by providing an automated false-discovery-rate-controlled analysis for data-independent acquisition in metabolomics.