Membrane-anchored DNA nanojunctions enable closer APC-T cell contact in elevated T-cell receptor triggering
Yulin Du, Liping Qiu*, and Weihong Tan* et al. from Hunan University develop membrane-anchored geometrically stable DNA nanojunctions to decrease intermembrane spacing at the close contact zone, leading to the exclusion of tyrosine phosphatase CD45 protein and enhancement of T-cell signalling.
The enhanced permeability and retention (EPR) effect of tumours is a topic of debate in nanomedicine community. To address this, we established a single-vessel quantitative analysis method (nano-ISML) to reveal heterogeneity of tumour vascular permeability.
Photothermal nanofibers were developed comprised of light-sensitive iron oxide nanoparticles (IONPs) embedded in electrospun nanofibers. We demonstrated that embryonic stem cells and human T cells, transfected with such nanofibers are in excellent health and retain their therapeutic functionality.
Our understanding of how biomolecules redirect the fate and impact of nanomaterials in the environment is rapidly advancing. We present the emerging work, along with our perspective on next steps in eco-corona studies.