Nature Biotechnology
A monthly journal covering the science and business of biotechnology, with new concepts in technology/methodology of relevance to the biological, biomedical, agricultural and environmental sciences.
Improving the versatility of CRISPR genome editing using a hybrid approach. By Jason Moffat
CHyMErA - a new CRISPR-based tool allows simultaneous genome editing at multiple sites to learn how different genomic sites and DNA stretches co-operate in health and disease.
Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces
Pharmaceutically important polyketides are produced during the stationary phase of growth of Streptomyces species in fermenters. The source of intracellular metabolites that are funneled into polyketide biosynthesis has proven elusive. We uncover the mystery and devised a titer improvement strategy.