CHyMErA - a new CRISPR-based tool allows simultaneous genome editing at multiple sites to learn how different genomic sites and DNA stretches co-operate in health and disease.
Pharmaceutically important polyketides are produced during the stationary phase of growth of Streptomyces species in fermenters. The source of intracellular metabolites that are funneled into polyketide biosynthesis has proven elusive. We uncover the mystery and devised a titer improvement strategy.
Introducing students to the art of the "chalk talk" and incorporating active learning activities to a graduate bioscience classroom