To fabricate a stable device-tissue interface, the bundles of carbon nanotubes fibres were twisted to form a hierarchical structure that mimic the native tissues. After modification, the sensing fibres could realize the long-term monitoring of multiple disease biomarkers in vivo.

Pharmaceutically important polyketides are produced during the stationary phase of growth of Streptomyces species in fermenters. The source of intracellular metabolites that are funneled into polyketide biosynthesis has proven elusive. We uncover the mystery and devised a titer improvement strategy.