Dynamic gene expression patterns orchestrate cellular functions. To understand the link between dynamic behaviour and cellular phenotype, and to direct cell fate in a user-defined way, tools enabling precise tuning of gene activation levels and temporal dynamics were developed.

Behind the paper "How does the emerging patent case law in the US and Europe affect precision medicine?"

In the eye, a tiny pit in the central retina provides us the clearest vision of all. This region contains the highest number of cone photoreceptors – responsible for our daylight, high acuity vision. Unfortunately, several diseases lead to the degeneration of these photoreceptor cells.

Using next-generation sequencing, we show that adeno-associated virus (AAV) DNA can cut-and-paste into CRISPR-induced breaks in the host genome.