Pharmaceutically important polyketides are produced during the stationary phase of growth of Streptomyces species in fermenters. The source of intracellular metabolites that are funneled into polyketide biosynthesis has proven elusive. We uncover the mystery and devised a titer improvement strategy.

Nanotechnologies and microbiome are both important fields in novel cancer therapy. Linking these two fields together, we asked what opportunities may exist? Our recent review discusses key opportunities in applying nanotechnologies towards manipulating the microbiome for cancer treatment.

Using a FokI fusion design, we show that Type I CRISPR-Cas systems can be expressed, reconstituted, and faithfully trafficked to the nucleus for genome engineering in human cells

With a need to develop new non-opioid analgesics, pH-responsive nanoparticles may offer an alternative strategy for improving analgesic drug efficacy and duration of action.