Our team at The Kidney Project chose a biohybrid approach to tissue engineering a universal donor kidney that mimics the tandem filtration-concentration physiology of a healthy kidney. Here, we show that cellular scaffolds can double as immunological barriers between host and allogeneic cells.
Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching
Understanding the conformational coupling mechanism between a protein and a conjugated fluorophore enables structure-based biosensor design
Streamlining DNA Mutation Detection: A Breakthrough with Phosphorothioated DNA-guided Endonuclease Excision
Detecting low-frequency DNA mutations remains a daunting task due to the background noise caused by wild-type (WT) DNA. In this article, we present a recent breakthrough that simplifies DNA mutation detection by eliminating WT DNA background using phosphorothioated DNA-guided endonuclease excision.