Stories behind the paper “Restoration of dystrophin expression in mice by suppressing a nonsense mutation through the incorporation of unnatural amino acids” that was recently published in Natural Biomedical Engineering.
We recently developed oligonucleotide libraries purification technology called "MOPSS". We repurposed next generation sequencing (NGS) instrument for massively parallel purification of oligonucleotides libraries and we believe that MOPSS will flourish nucleic acid-based technologies.
Current methods for detecting activity of lysyl oxidases lack specificity and do not provide information on how much activity is occurring in situ. Hydrazide reagents can be used to measure their in situ activity levels in a practicable, sensitive, and specific manner.
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