Nanoparticle delivery of CRISPR tools

Gold nanoparticles carrying Cas9 ribonucleoprotein and donor DNA, and complexed with endosomal disruptive polymers, correct the DNA mutation that causes Duchenne muscular dystrophy in mice, with minimal off-target effects.

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Pep Pàmies

Chief Editor, Nature Biomedical Engineering, Nature Research

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Pep Pàmies about 3 years ago

The cover illustrates the delivery of Cas9 ribonucleoprotein and donor DNA by gold nanoparticles, for the correction of a gene mutation.

Image design by Karen Moore.