Ultrasound-enabled targeting of specific brain circuits
The combination of focused ultrasound and virally encoded receptors engineered to be activated by a designer drug enables, on intravenous administration of the drug, the non-invasive activation or inhibition of brain regions in mice, with cell-type and spatiotemporal specificity.
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The cover illustrates the non-invasive modulation of brain circuits, with cell-type and spatiotemporal specificity, via focused ultrasound and virally encoded receptors engineered to be activated by a designer drug.
See Szablowski et al., https://doi.org/10.1038/s41551-018-0258-2
Image: Maayan Harel and Jerzy Szablowski. Cover design: Alex Wing.