Traceless isolation of killer T cells via DNA aptamers

DNA aptamers that specifically bind to the T-cell marker CD8 and that can be displaced by a complementary oligonucleotide enable the isolation, at high purity and yield, of CD8+ T cells for CAR-T cell therapies.

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Pep Pàmies

Chief Editor, Nature Biomedical Engineering, Nature Research

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Pep Pàmies about 1 year ago

The cover illustrates the isolation of CD8+ T cells by magnetic microbeads functionalized with DNA aptamers that specifically bind to the T-cell marker CD8 and and that can be displaced by a complementary oligonucleotide.


See Kacherovsky et al.

Image credit: Hang Yu Lin