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Traceless isolation of killer T cells via DNA aptamers

DNA aptamers that specifically bind to the T-cell marker CD8 and that can be displaced by a complementary oligonucleotide enable the isolation, at high purity and yield, of CD8+ T cells for CAR-T cell therapies.
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Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research
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Traceless aptamer-mediated isolation of CD8+ T cells for chimeric antigen receptor T-cell therapy - Nature Biomedical Engineering

DNA aptamers that specifically bind to the T-cell marker CD8 and can be displaced by a complementary oligonucleotide enable the isolation, at high purity and yield, of CD8+ T cells for chimeric antigen receptor T-cell therapies.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research

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Go to the profile of Pep Pàmies
Pep Pàmies
almost 3 years ago

The cover illustrates the isolation of CD8+ T cells by magnetic microbeads functionalized with DNA aptamers that specifically bind to the T-cell marker CD8 and and that can be displaced by a complementary oligonucleotide.

See Kacherovsky et al.

Image credit: Hang Yu Lin

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