Nuclear wrinkling and chromatin state mediate stiffness-induced breast cancer

In a 3D model of breast cancer, a stiff extracellular matrix promotes a tumorigenic phenotype through broad changes in chromatin accessibility and in the activity of histone deacetylases and the transcription factor Sp1.
The cover illustrates that a stiff extracellular matrix induces a tumorigenic phenotype in mammary epithelial cells through nuclear wrinkling and broad changes in chromatin accessibility. Image: Dr. Ryan Stowers, University of Santa Barbara. Cover design: Alex Wing.