Therapeutic extracellular vesicles produced at scale
A cellular-nanoporation method produces large quantities of exosomes containing therapeutic mRNAs and targeting peptides that restore tumour-suppressor function in mice with orthotopically implanted phosphatase and tensin homologue (PTEN)-deficient brain gliomas.
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The cover illustrates the production, via cellular nanoporation, of large quantities of extracellular vesicles loaded with endogenously transcribed therapeutic mRNAs and targeting peptides.
See Yang, Z. et al.
Image: Ella Marushchenko. Cover design: Alex Wing