Therapeutic extracellular vesicles produced at scale

A cellular-nanoporation method produces large quantities of exosomes containing therapeutic mRNAs and targeting peptides that restore tumour-suppressor function in mice with orthotopically implanted phosphatase and tensin homologue (PTEN)-deficient brain gliomas.

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Pep Pàmies

Chief Editor, Nature Biomedical Engineering, Nature Research


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over 1 year ago

The cover illustrates the production, via cellular nanoporation, of large quantities of extracellular vesicles loaded with endogenously transcribed therapeutic mRNAs and targeting peptides.

See Yang, Z. et al.

Image: Ella Marushchenko. Cover design: Alex Wing