Fluidically linked organ chips
Physiological modelling of first-pass metabolism using data from a robotic instrument that fluidically links relevant organ chips predicts human pharmacokinetic parameters for orally administered nicotine and for intravenously injected cisplatin.
The cover illustrates a set of fluidically linked vascularized organ chips for the prediction of the pharmacokinetics of orally administered drugs or intravenously injected drugs in humans.
Image: Donald Ingber and Lei Jin, Wyss Institute at Harvard. Cover design: Alex Wing.