Fluidically linked organ chips

Physiological modelling of first-pass metabolism using data from a robotic instrument that fluidically links relevant organ chips predicts human pharmacokinetic parameters for orally administered nicotine and for intravenously injected cisplatin.

The cover illustrates a set of fluidically linked vascularized organ chips for the prediction of the pharmacokinetics of orally administered drugs or intravenously injected drugs in humans.

See Noval et al. and Herland et al.

Image: Donald Ingber and Lei Jin, Wyss Institute at Harvard. Cover design: Alex Wing.

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