Intratumoural activation of CAR T cells via focused ultrasound

The activity of engineered T cells within tumours can be controlled via the heat generated by pulses of focused ultrasound by modifying the cells to express a chimeric antigen receptor under the control of a promoter for the heat-shock protein.

Like Comment
Read the paper

Pep Pàmies

Chief Editor, Nature Biomedical Engineering, Nature Research

Comments

Go to the profile of Pep Pàmies
6 months ago

The cover illustrates that T cells can be engineered to express a chimaeric antigen receptor within tumours when heat is locally generated by pulses of focused ultrasound.

See Wu et al.

Image: Lan-Tao Gou, Yinglin Situ and Yiqian Wu. Cover design: Allen Beattie.