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Intratumoural activation of CAR T cells via focused ultrasound

The activity of engineered T cells within tumours can be controlled via the heat generated by pulses of focused ultrasound by modifying the cells to express a chimeric antigen receptor under the control of a promoter for the heat-shock protein.
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Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research
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Control of the activity of CAR-T cells within tumours via focused ultrasound - Nature Biomedical Engineering

The activity of engineered T cells within tumours can be controlled via the heat generated by pulses of focused ultrasound by modifying the cells to express a chimeric antigen receptor under the control of a promoter for the heat-shock protein.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research

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Go to the profile of Pep Pàmies
Pep Pàmies
over 1 year ago

The cover illustrates that T cells can be engineered to express a chimaeric antigen receptor within tumours when heat is locally generated by pulses of focused ultrasound.

See Wu et al.

Image: Lan-Tao Gou, Yinglin Situ and Yiqian Wu. Cover design: Allen Beattie.

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