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Nuclear mechanosensing and chromatin reorganization in cardiac cells

Strain maps of cardiomyocyte nuclei during contraction indicate that, by integrating environmental mechanical cues, the nuclei of cardiomyocytes stabilize the fate of cells through the reorganization of epigenetically marked chromatin.
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Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research
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Nuclear deformation guides chromatin reorganization in cardiac development and disease - Nature Biomedical Engineering

Strain maps of cardiomyocyte nuclei during contraction indicate that, by integrating environmental mechanical cues, the nuclei of cardiomyocytes stabilize the fate of cells through the reorganization of epigenetically marked chromatin.

The cover illustrates that, in cardiomyocytes under contraction, epigenetically marked chromatin preferentially accumulates in the periphery of the cell’s nucleus.

See Seelbinder et al.

Image: Benjamin Seelbinder, University of Colorado Boulder. Cover design: Alex Wing.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research

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