The cover illustrates that, in cardiomyocytes under contraction, epigenetically marked chromatin preferentially accumulates in the periphery of the cell’s nucleus.
Nuclear mechanosensing and chromatin reorganization in cardiac cells
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Nuclear deformation guides chromatin reorganization in cardiac development and disease - Nature Biomedical Engineering
Strain maps of cardiomyocyte nuclei during contraction indicate that, by integrating environmental mechanical cues, the nuclei of cardiomyocytes stabilize the fate of cells through the reorganization of epigenetically marked chromatin.