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Peptide-boosted uptake of CRISPR enzymes

The yields of edited primary human lymphocytes can be increased substantially, with respect to those obtained via electroporation, by delivering a CRISPR ribonucleoprotein alongside an amphiphilic peptide identified via screening.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research
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Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes - Nature Biomedical Engineering

The yields of edited primary human lymphocytes can be increased substantially, with respect to those obtained via electroporation, by delivering a CRISPR ribonucleoprotein alongside an amphiphilic peptide identified via screening.

The cover illustrates that a peptide identified via screening aids the delivery of CRISPR ribonucleoprotein into cells, increasing the yield of edited primary human lymphocytes. 

See Foss et al.

Image: Credit. Cover design: Marina Spence.
Go to the profile of Pep Pàmies
Pep Pàmies
Chief Editor, Nature Biomedical Engineering, Nature Research

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