Prolonged local anaesthesia via nanofibres mimicking interactions on a sodium channel
A self-assembling supramolecular delivery system for site-1 sodium channel blockers designed to mimic specific interactions on voltage-gated sodium channels led to prolonged nerve blockade and to reduced systemic toxicity in rats.
Published
The cover illustrates that self-assembled nanofibres carrying site-1 sodium channel blockers and designed to mimic specific interactions of the blockers with peptide sequences on voltage-gated sodium channels led to prolonged nerve blockade with low systemic toxicity in rats.
Image: Daniel S. Kohane, Harvard Medical School, Boston Children’s Hospital; Tianjiao Ji, National Center for Nanoscience and Technology; Xin Zhou, Fantastic Color Co., Ltd. Cover design: Allen Beattie.
