Prolonged local anaesthesia via nanofibres mimicking interactions on a sodium channel

A self-assembling supramolecular delivery system for site-1 sodium channel blockers designed to mimic specific interactions on voltage-gated sodium channels led to prolonged nerve blockade and to reduced systemic toxicity in rats.

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The cover illustrates that self-assembled nanofibres carrying site-1 sodium channel blockers and designed to mimic specific interactions of the blockers with peptide sequences on voltage-gated sodium channels led to prolonged nerve blockade with low systemic toxicity in rats.

Image: Daniel S. Kohane, Harvard Medical School, Boston Children’s Hospital; Tianjiao Ji, National Center for Nanoscience and Technology; Xin Zhou, Fantastic Color Co., Ltd. Cover design: Allen Beattie.

Pep Pàmies

Chief Editor, Nature Biomedical Engineering, Nature Research