The cover illustrates that self-assembled nanofibres carrying site-1 sodium channel blockers and designed to mimic specific interactions of the blockers with peptide sequences on voltage-gated sodium channels led to prolonged nerve blockade with low systemic toxicity in rats.
Prolonged local anaesthesia via nanofibres mimicking interactions on a sodium channel
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Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel - Nature Biomedical Engineering
A self-assembling supramolecular delivery system for site-1 sodium channel blockers designed to mimic specific interactions on voltage-gated sodium channels led to prolonged nerve blockade and to reduced systemic toxicity in rats.