In this Nature paper the authors take us all the way from a rural Thai population with lower-than-usual pathogenic Staphylococcus aureus colonization in the gut (and nose), through realizing that probiotic Bacillus inclusion means staphylococcal exclusion, to discovering that signalling using fengycins by the probiotic bacillus eliminates Staphylococcus colonization by interfering with pathogen quorum sensing. Mechanisms underpinning probiotic efficacy could pave the way to microbiome modulation to improve human health. Michael Otto, the lead author, tells the story behind the paper here.
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