Vaccine designs that elicit a robust immune response against a pathogen without causing unneeded inflammation are in high demand. To ‘tune’ vaccines and achieve this balance, the adjuvant and its mode of delivery are critical. In a paper by Robert Seder and colleagues, the authors explore the use of different types of polymers to deliver Toll-like receptor agonists, a type of powerful adjuvant, and find that polymer-adjuvants best suited for vaccine design are those that form particles. The paper also examines factors that influence why some polymers work better than others.
The above image relates to the Seder and colleagues paper, available now at this link.