A new tool to study the immune system



Irina D. Chudakova and Dmitriy M. Chudakov

Beyond fighting infection, the immune system has important roles in many systems in the body. To study the involvement of T cells and B cells, researchers often sequence their T cell and B cell receptors (TCRs and BCRs), which provide insights into their clonal diversity. However, even more useful would be to gather T cell and B cell receptor information together with the transcriptomic profile of their tissue sample of origin. Now, in a paper published in Nature Biotechnology, Dmitriy Chudakov and colleagues report a software tool that enables extracting TCR and BCR sequences from bulk RNA-seq data sets. Because RNA-seq data is already available for thousands of tumor samples, this method will allow revisiting those data sets to extract important information.

Irene Jarchum

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