The CRISPR children - some reading

Much has been published about The 'CRISPR babies' who are now 'CRISPR children.' Here is some material.

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For my story The CRISPR Children in Nature Biotechnology, I consulted a lot of material. There are some links in the piece. Here is a quite incomplete list of items for your consideration. 

This is the story that broke the news about the ‘CRISPR babies:

Regolado, Antonio MIT Technology Review, Exclusive: Chinese scientists are creating CRISPR babies. November 25, 2018 

According to sources, this story by the AP had long been in the works. When MIT Technology Review ran the story, the AP ran its story. Marchione, M. Associated Press, Nov. 26, 2018  Also here. 

There were follow-up stories such as these: 

Regalado, A. Rogue Chinese CRISPR scientist cited US report as his green light. MIT Technology Review  (27 November 2018).

Marchione, M. & Larson, C. Could anyone have stopped gene-edited babies experiment? AP News  (2 December 2018).

Regalado, A. China’s CRISPR babies: Read exclusive excerpts
from the unseen original research. MIT Technology Review (3
December 2019).

Here is a selection of more news articles and editorials

Cohen, J. The Untold story of the ‘circle of trust’ behind the world’s first gene-edited babies. Science 1 August (2019) 

Larson, C. Gene-editing scientist kept much of his work secret. AP Nov 27, 2018. 

Begley, S and Jospeh, A. The CRISPR Shocker, Stat, Dec 17, 2018

Cyranoski, D. CRISPR-baby scientist fails to satisfy his critics Nature 6 Dec 2018 564, p.13-14 (2018)

Ledford, H. CRISPR babies When will the world be ready? 20 June Nature 570, 292-296 
2 august 2019 vol 365, (2019)

WHO takes up CRISPR babies Nature Biotechnology 39, 901(2021)
https://www.nature.com/articles/s41587-021-01027-x

Dickenson, D., Darnovsky, M. Nature Biotechnology 37, 355-357 (2019) 

Ryder, Sean #CRISPR babies: Notes on a Scandal 
The CRISPR Journal. Dec 2018.355-357.http://doi.org/10.1089/crispr.2018.29039.spr

Among the published books on the subject are these:  

Henry Greely CRISPR People The Science and Ethics of Editing Humans (MIT Press 2021) 
Kiran Musunuru The CRISPR Generation The Story of the World’s First Gene-Edited Babies
Kevin Davies Editing Humanity (Pegasus 2020)
Françoise Baylis Altered Inheritance CRISPR and the Ethics of Human Genome Editing 
(Harvard University Press 2019)
Walter Isaacson The Code Breaker (Simon& Schuster 2021)
Eben Kirksey The Mutant Project (St Martin’s Press, New York 2020) 

Some reports about human gene-editing 

WHO Expert Advisory Committee on Developing Global Standards for Governance
and Oversight of Human Genome Editing, A Framework for Governance, 2021 


WHO Expert Advisory Committee on Developing Global Standards for Governance
and Oversight of Human Genome Editing, Recommendations, 2021 

WHO Expert Advisory Committee on Developing Global Standards for Governance
and Oversight of Human Genome Editing, Position Paper, 2021 

National Academies of Sciences, Engineering, and Medicine. Second International Summit on Human Genome Editing: Continuing the Global Discussion: Proceedings of a Workshop— in Brief (National Academies Press, 2019); https://doi.org/10.17226/25343

Heritable human genome editing: report of the International Commission. National Academy of Medicine, National Academy of Sciences and the Royal Society; 2020. 

Human Genome Editing: Science, Ethics, and Governance (National Academies Press, 2017)

Some commentaries, reviews and research papers in journals 

Doudna, J. and Sternberg, S. A Crack in Creation (Houghton Mifflin Harcourt, 2017)

Editorial Nature Biotechnology 3, 1 (2019) 
Editorial Nature Biotechnology 38, 1 (2020). When the world needs to know
Baylis, F. Nature Biotechnology  38,  271 (2020).

Krimsky, S. Ten ways in which he Jiankui violated ethics Nature Biotechnology 37, 19-20 (2019) 

Adashi, E.Y, Cohen, G What would responsible remedial human germline editing look like Nature Biotechnology 38, 398-400 (2020) 

Alanis-Lobato, G et al. Proc. Nat. Acad. Science https://doi.org/10.1073/pnas.2004832117
(2020)

Turocy, J, Adashi, E. and Egli, A. Cell https://doi.org/10.1016/j.cell.2021.02.036 (2021) 

Jarvis, Gavin. F1000 Research 2016, 5:2765 Last updated: 25 JUN 2020  
https://f1000research.com/articles/5-2765/v2

Grishin, D et al. Citizen-centered, auditable and privacy-preserving population genomics Nature Computational Science 1, 192-198 (2021)

Videos and material by or co-authored by He Jiankui 

Retracted: Draft Ethical Principles for Therapeutic Assisted Reproductive Technologies
He Jiankui, Ryan Ferrell, Chen Yuanlin, Qin Jinzhou, and Chen Yangran
Published Online:26 Nov 2018 https://doi.org/10.1089/crispr.2018.0051

“The Editor-in-Chief of The CRISPR Journal has regretfully made the decision to retract the Perspective by He Jiankui et al., entitled, “Draft Ethical Principles for Therapeutic Assisted Reproductive Technologies,” published online ahead of print on November 26, 2018, in The CRISPR Journal.

…”This article was originally published with no conflict of interest information provided by the authors. The editors corresponded via email over several weeks with Dr. He, who willingly supplied updated information regarding funding sources, company ties, patent applications and a clinical trial registration.

However, it has since been widely reported that Dr. He conducted clinical studies involving germline editing of human embryos, resulting in several pregnancies and two alleged live births. This was most likely in violation of accepted bioethical international norms and local regulations. This work was directly relevant to the opinions laid out in the Perspective; the authors' failure to disclose this clinical work manifestly impacted editorial consideration of the manuscript.”…

He Jiankui, Michael Deem Hetereogeneous Diversity of Spacers within CRISPR  
Physical Review Letters 105, 128102 (2010).

Ning Jiang et al. Lineage Structure of the Human Antibody Repertoire in Response to Influenza Vaccination
Sci Transl Med 5, 171ra19 (2013) doi:10.1126/scitranslmed.3004794

He Jiankui 
Presentation at the Second International Summit on Human Genome Editing Nov 27-29, 2018 
His talk on Day 2, session 3, Human Embryo Editing 
Starts at 1 hour 17 minutes. 
https://www.nationalacademies.org/event/11-27-2018/second-international-summit-on-human-gene-editing

He Jiankui 
About Lulu and Nana: Twin Girls born healthy after gene surgery as single-cell embryos. 
https://www.youtube.com/watch?v=th0vnOmFltc

He Jiankui 
Draft Ethical Principles of Therapeutic Assisted Reproductive Technologies. 
https://www.youtube.com/watch?v=MyNHpMoPkIg

He Jiankui 
Designer Baby is an Epithet
https://www.youtube.com/watch?v=Qv1svMfaTWU

He Jiankui 
Why we Choose HIV and CCR5 first
https://www.youtube.com/watch?v=aezxaOn0efEn

He Jiankui, Evaluating the safety of germline genome Editing in Human, Monkey and Mouse Embryos Cold Spring Harbor Lab Symposium July 29, 2017 

(on the right: Rose_Carson/Getty Images) 

Vivien Marx

Journalist , Nature Portfolio