I am heading a research group interested in synthetic biology and systems metabolic engineering in whole-cell and cell-free systems. We develop in silico and experimental methods to search and design chemical and biological networks constrained by experimental data. The applications of our work include synthetic metabolic pathway design, building and testing for bioproduction, biosensing, and biocomputing. Other activities include structure-activity, sequence-function relationships, and the design of experiments using active and reinforcement machine learning methods.