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Biomaterials Biomedical analytics Biomedical imaging Biomedical sensors Biomolecular engineering Diagnostics Drug and cell delivery Genomics Imaging Nanobiotechnology Nanomedicine Nucleic acid therapies Precision medicine Protein engineering Proteomics Sequencing technology Smart biosensors and diagnostics

Streamlining DNA Mutation Detection: A Breakthrough with Phosphorothioated DNA-guided Endonuclease Excision

Detecting low-frequency DNA mutations remains a daunting task due to the background noise caused by wild-type (WT) DNA. In this article, we present a recent breakthrough that simplifies DNA mutation detection by eliminating WT DNA background using phosphorothioated DNA-guided endonuclease excision.