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Recent Comments
It has been an exciting journey to see our ultra-long-acting injectable formulation make it through several years of development and learnings along the way to finally bring it to a place where we demonstrated the ability to achieve critical milestones including: 1) the ability to develop a stable and safe injectable formulation of cabotegravir (CAB); 2) sustain plasma CAB levels in macaques above the benchmark for HIV pre-exposure prophylaxis (PrEP; 4x PA-IC90) for more than 6 months; 3) demonstrate the ability to safely remove the implant and reduce CAB plasma levels by up to 100-fold within 1 week; and 4) demonstrate 100% protection in macaques over several months which represents to our knowledge the longest documented PrEP activity seen with a single CAB administration.
I am excited to continue to move forward this technology and pave the way towards clinical translation to ultimately make an impact to curb the HIV epidemic.