Zhiyuan Tian

Ph. D., Professor , University of Chinese Academy of Sciences

University of Chinese Academy of Sciences
China

About Zhiyuan Tian

Our research group is interested in photoactive functional materials and their potential applications. Specifically, we focus on the design and synthesis of functional materials with stimuli-response features to light and their potential applications in biological imaging (super-resolution fluorescence imaging and multimodality correlative imaging), biological optical detection (mapping of tumor markers) and therapy (photoactivated synergistic antitumor with multilevel mechanisms) and etc.

Subject

Biomaterials Biomedical imaging Diagnostics Drug and cell delivery Micro- and nanobiotechnology Nanomedicine

Challenge-oriented design of nanoagent enabling dual-mitochondrial-damage synergistic antitumor therapy

We developed a new type of MOFs-based core-shell nanoagents that enables near infrared (NIR) light-triggered two distinct antitumor mechanisms, namely oxidative stress and calcium overload, with both of them contributing to the mitochondria-dysfunction-associated eradication of tumor cells.